They were first reported in natural soils by Newman and Tate They also have favourable dispersing properties and so are investigated as a possible new class of superplasticizers. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
A weight percent wt. Throughout this application, various publications are referenced. Phosphonates are present mainly as Ca and Mg-complexes in natural waters and therefore do not affect metal speciation or transport. Phospha-Mannich reaction employing primary amine has been well exploited Ordonez et al. An example haloalkoxy group is OCF3. Exemplary five-membered ring heteroaryls are thienyl, furyl, pyrrolyl, imidazolyl, thiazolyl, oxazolyl, pyrazolyl, isothiazolyl, isoxazolyl, 1,2,3-triazolyl, tetrazolyl, 1,2,3-thiadiazolyl, 1,2,3-oxadiazolyl, 1,2,4-triazolyl, 1,2,4-thiadiazolyl, 1,2,4-oxadiazolyl, 1,3,4-triazolyl, 1,3,4-thiadiazolyl, and 1,3,4-oxadiazolyl.
It will be further understood that the endpoints of each of the ranges are significant both in relation to the other endpoint, and independently of the other endpoint. Ring-forming carbon atoms of a cycloalkyl group can be optionally substituted by oxo or sulfido e. It is contemplated that each disclosed derivative can be optionally further substituted.
In various aspects, each alkyl group has, independently, 1 to 6, 1 to 4, or 1 to 3 carbon atoms. For example, piperidinyl is an example of a 6-membered heterocycloalkyl ring, pyrazolyl is an example of a 5-membered heteroaryl ring, pyridyl is an example of a 6-membered heteroaryl ring, and 1,2,3,4-tetrahydro-naphthalene is an example of a membered cycloalkyl group. This factor was attributed to adsorption rather than biodegradation. These phosphonates are the structural analogues to the well-known aminopolycarboxylate such as EDTA. They also have favourable dispersing properties and so are investigated as a possible new class of superplasticizers. The stability of the metal complexes increases with increasing number of phosphonic acid groups.
An example haloalkoxy group is OCF3. In various aspects, the heteroaryl is a five-membered or six-membered heteroaryl ring. Niche uses[ edit ] In conjunction with organosilicates, phosphonates are also used to treat "sudden oak death", which is caused by the fungus-like eukaryote Phytophthora ramorum. Exemplary six-membered ring heteroaryls are pyridyl, pyrazinyl, pyrimidinyl, triazinyl and pyridazinyl.
VX Thiol form A thiophosphonate group is a functional group related to phosphonate by substitution of an oxygen atom for a sulphur. In various aspects, the alkenyl moiety contains 2 to 6, 2 to 4, or 2 to 3 carbon atoms. Cycloalkyl groups can have 3, 4, 5, 6, 7, 8, 9, or 10 ring-forming carbons C
For example, an azetidine ring may be attached at any position of the ring, whereas an azetidinyl ring is attached at the 3-position. Also disclosed are pharmaceutical compositions comprising the disclosed compounds.
Examples include C, C, and the like. Most notably, these enzymes include those that produce the intermediates of cholesterol biosynthesis. These needs and others are met by the present invention. In addition, thiomorpholino-methyl phosphonic acid is known as an effective corrosion inhibitor for carbon steel in seawater Amar et al. Dialkyl phosphonates stable towards hydrolysis and oxidation due to the lack of lone pair electrons have been extensively used for this phosphonylation to form a C—P bond Stawinski and Kraszewski Acc.